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Ewing's sarcoma is a
malignant (cancerous) bone tumor which affects children. Ewing
's sarcoma can occur any time during childhood, but usually
develops during puberty, when bones are growing rapidly. The
tumor may arise anywhere in the body, usually in the long bones
of the
arms and legs, the pelvis, or the chest. It may also develop in
the skull or the flat
bones of the trunk. There are few symptoms. The most common is
pain and occasionally swelling at the site of the tumor.
Children may also break a bone at the site of the tumor after a
seemingly minor trauma (pathologic fracture). Fever may also be
present. |
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Incidence |
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Ewing sarcoma family
tumors are the second most common type of bone cancer in
children and adolescence. |
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Approximately 200 new
cases of this type of tumor are diagnosed in
the United States per year. |
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Almost 50 percent of
patients with Ewing family of tumors are
between 10 and 20 years of age. |
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Treatment Strategies |
From past
experience, it is clear that most patients who are treated with
local therapy alone (surgery and/or radiation therapy), will
have tumor recurrence, usually at a distant site. For this
reason, chemotherapy has become part of the standard treatment
for Ewing family of tumors. Chemotherapy kills tumor cells at
the site of primary disease as well as tumor cells in other
areas of the body that cannot be seen. Vincristine,
cyclophosphamide, doxorubicin, etoposide and ifosfamide are the
most commonly used chemotherapeutic agents.
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